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Nervous System

Neuron Puzzle

Neuron Puzzle

Regular price $120.00 USD
Regular price Sale price $120.00 USD
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Explore inside a neuron with this colorful wooden puzzle featuring art by scientist David S. Goodsell. The Neuron Puzzle features large cellular regions which are subdivided into three different organic puzzle cut styles: maze, coral or matrix. Eight neuron shaped whimsy pieces are hidden within the puzzle. For an extra challenge, try to connect the neuron pieces into an alternate solution.

The watercolor painting depicts a cross-section of a brain cell's axon. The axon is the portion of a neuron that carries electrical impulses to other cells. Artist and scientist David Goodsell uses watercolor to beautifully illustrate the unseen complexities of microscopic biological machinery. His work uses information from atomic structure analysis, electron microscopy, and biochemical analysis to make these illustrations as accurate as possible. A detailed description of all the proteins and structures depicted in the image can be found here.

Credit: Illustration by David S. Goodsell, RCSB Protein Data Bank. doi: 10.2210/rcsb_pdb/goodsell-gallery-030

The puzzle contains 8 neuron whimsies and our signature brain piece. There is an alternative puzzle solution that can be created with the neurons.


  • Contains 473 pieces, 14 x 10.5"
  • Digitally painted on 4mm maple plywood
  • Laser cut in Palenville, NY

made with math, science, + lasers
Since 2011, we've been crafting plywood puzzles that combine the artistry of classic jigsaws with the possibilities of new technology. We use custom software inspired by natural patterns to grow the intertwining shapes of the puzzle pieces. The organic forms are cut from plywood by a laser, resulting in a uniquely challenging puzzle crafted from premium materials. Each puzzle is made by us at our studio in the Catskill Mountains.

473 pieces, 14 x 10.5 inches
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Where are your products made?

Our puzzles and games are handcrafted with care. Most are made in the USA by the Janelle family; some are crafted by friends in Canada, Japan and Mexico and some right here in Albuquerque. Be sure to ask for recommendations.

What's the story behind Puzzled?

Puzzled® was born from a passion for play and the joy of bringing people together through the art of puzzling. Founded by Dan Janelle and Melanie Kintigh in Old Town Albuquerque, our store is a celebration of creativity, curiosity, and community. Drawing from a rich history of craftsmanship and a love for brain teasers, we offer an eclectic mix of handcrafted puzzles and games designed to challenge and delight minds of all ages. At Puzzled®, every piece tells a story, and every visit is an adventure waiting to unfold.

What is your shipping and returns policy?

We offer free shipping on US orders over $200, typically dispatching within 2 business days, often sooner. For items not immediately available, we'll reach out to discuss your options. Our shipments within the U.S. are primarily through USPS Priority Mail, with UPS for larger packages, aiming for a 2-4 day delivery.

For international shipping inquiries, please contact us directly. We strive for transparency in shipping costs, keeping them close to actual with a minimal handling fee.

Your satisfaction is paramount. If you’re not happy with your purchase, items in their original condition can be returned within 14 days for a refund or exchange. Contact us for return authorization and instructions.